Multiple myeloma and the pathways associated with it and TGF-B. see Research Paper

Multiple myeloma and the pathways associated with it and TGF-B. see discription of project - Research Paper Example These cells are also characterized by the somatic hyper mutation of the Ig genes extensively. The Multiple myeloma (MM) cells have 1- 3% of the cycling cells with a low rate of proliferation. (Kuehl and Bergsagel, 2012). MM leads to immune deficiency, renal dysfunction, anemia and bone lesions. In United States, its incidence level is at the rate of 20000 per year and records as the second hematopoietic malignancy. Though there is no cure for this disease yet, the survival rate has increased from 3 years to 6 years. (Kuehl and Bergsagel, 2012). The International system of staging has classified multiple myeloma to have three stages: Serum Beta 2 microglobulin , serum albumin, serum creatinine, and platelet count along with the age of the patients are used as the powerful key factors for determining the survival rate of the patients with multiple myeloma. The concentration of serum beta 2 microglobulin in renal filtrate was found to influence the kidney function and also the best indicator of tumor burden in the patients with multiple myeloma. A multivariate analysis has found that serum beta 2 immunoglobulin factor concentrations was independent of serum creatinine and serum albumin concentration and remains as an independent prognostic factor. In stage I, the beta 2 immunoglobulin concentration is 3.5 mg/ L along with serum albumin concentration as 3.5 g / dL. At stage II, is the intermediate stage median survival of about 44 months and the last stage is stage III with median survival of only 29 months and the beta 2 immu noglobulin concentration being 5.5 mg/ L. (Yun et al., 2006). Multiple myeloma is a less frequent fatal cancer in both men and women. Multiple myeloma cases constitute about 0.8% of the cancer cases annually. The most important factors that cause multiple myeloma was found to be Tobacco chewing, Alcohol consumption, Diet, Obesity, different physical activities, some hormonal factors, Ionizing radiation.

History of the Gospel of Mark Essay Example | Topics and Well Written Essays - 1250 words

History of the Gospel of Mark - Essay Example Researchers assert that the gospel of Mark was anonymously written but by tradition has been attributed to John Mark, the evangelist. It is also claimed that the content is thought to be the report of Simon Peter. Researchers also agree that the book was probably written between 50 and 70 A.D. in Italy or in Rome. Further, there is an indication of a secret book of Mark which so far has not had any significant impact on the history of Mark. The main evidence about the authorship and date of the gospel of Mark comes from the writing of Eusebius of Caesarea. Wettereau (as cited in Wikipedia) proposes that Eusebius of Caesarea was the bishop of Caesarea. Eusebius is often referred to as the father of Church history because of his recording of the history of the early Christian Church. Eusebius used sources such as Papias to obtain his information. Papias was a church leader in the first half of the second century and was later canonized as a saint. Eusebius (as cited in Kirby 2007and Malick 2007) quotes Papias as reporting that, Mark having become the interpreter of Peter wrote down accurately whatsoever he remembered. It was not, however, in exact order that he related the sayings or deeds of Christ. For he neither heard the Lord nor accompanied Him. But afterwards, as I said, he accompanied Peter, who accommodated his instructions to the necessities [of his hearers], but with no intention of giving a regular narrative of the Lord’s sayings. Wherefore Mark made no mistake in thus writing some things as he remembered them. For of one thing he took especial care, not to omit anything he had heard, and not to put anything fictitious into the statements. Two other sources ascribing the authorship of the gospel of Mark to John Mark include the writing of Peter himself in the book of Acts and the motivation of the early church. Kirby 2007 posits that the speech of Peter, an apostle of Jesus Christ, in Acts 10:34- 40, can serve as a